Welsh-born of Ghanaian descent Ethan Ampadu's first senior goal could not help Spezia avoid relegation from Serie A as they lost 3-1 to Hellas Verona in a play-off.
The on-loan Chelsea defender equalised after David Faraoni had given Verona the lead.
Cyril Ngonge's double extended Verona's leada before scorer Faraoni was red carded.
M'Bala Nzola missed a penalty for Spezia, who are relegated after three seasons in Italy's top-flight league.
Ampadu, who has spent the season on loan at Spezia, has been included in Wales' squad for this month's Euro 2024 qualifiers against Armenia and Turkey.
He was eligible to represent Ghana at the senior national team level but he opted for Wales.
