Coach Augustine Evans Adortey named a very strong line up that included Felix Kyei, Jean Vital, Joshua Agyemang, Hamidu Fatawu, last week hero Jonathan Sowah and others for the game.
The Nigerians begun on a blistering note and came close to snatching the lead in just five minutes from kickoff but Franck Mawuena had his effort missed the target by inches.
The Ghanaian champions looked very calm and resolute in the opening minutes hoping to avoid an early goal.
Franck Mawuena followed up with another two dangerous opportunities subsequently but once again he couldn't make them count as it remained goalless after twenty minutes.
In the second half, the Sky Blue Stars returned into the game on a blistering note and attacked right from onset in search of the goal to avoid elimination.
On the 64th minute, Adams Olamilekan with another golden chance to grab the opener but his effort went off the upright.
Medeama SC looked only dominant in terms of possession, but made no goal incursions.
Finally, Remo Stars scored on the 72nd minute to snatch the lead after goalkeeper Felix Kyei struggled to handle as it rolled into the net.
It finished 1-0 after full time and the game travelled to penalty shootouts. Medeama SC won 3-2 on penalties to cruise into the next round of the competition.
