Both Qatar and Senegal will be hoping to record their first victory at the mundial at the Al Thumama Stadium.
Host nation, Qatar lost their opening game by 2:0 to Ecuador, whereas Senegal also succumbed to a late 2:0 defeat to the Netherlands.
Any of the two sides that loses is almost out of the competition, which makes this fixture a no brainer for both sides.
Qatar are the only host nation in history to lose their opening game at the World Cup.
Qatar head coach, Félix Sanchez said "the responsibility and nerves got the best of us" after their lost to Ecuador.
Almoez Ali and Akram Afif dissapointed in the attacking third as they failed to shot at goal.
Senegal were impressive for majority of the game until Cody Gakpo scored the opener for Netherlands on the 84th minute.
Two errors from Edouard Mendy, which resulted in the goals they conceded, cost them a lot as they come into this fixture.
Missing the services of captain Sadio Mane was always going to be a huge problem as it was evident in their first game.
Aliou Cisse will hope his men find their mojo against Qatar to increase their chances of qualifying from the group.
MATCH STATISTICS (last five matches)
Qatar: 4 wins, 1 defeat
Senegal: 2 wins, 2 defeats, 1 draw
HEAD TO HEAD
No game between the two sides.
TV CHANNELS
GoTV, DSTV, beIN Sports, BBC, ITV and Fox.
MATCH OFFICIALS
Referee: Antonio Mateu Lahoz.
Assistant Referee 1 and 2: Pau Cebrian Devis and Roberto Diaz Perez del Palomar.
Fourth Official: Kevin Ortega.
KICKOFF: 13:00 GMT (1:00pm)
By: Abdul Razak Salim