FC Samartex will hope to keep firm grip at the top of the table when they host Accra Great Olympics on Saturday.
Aduana FC will host relegation-threatened Karela United at the Nana Agyeman Badu I Park in Dormaa this Saturday, marking their return home after a 1-0 defeat against Bibiani GoldStars FC last weekend.
Leicester City have been promoted to the Premier League after Leeds United were thumped by QPR.
Champions Medeama SC will welcome giants Asante Kotoko to the Akoon Park in arguably the biggest fixture of Ghana Premier League match-week 28.
On a thrilling night of football, Al Ahly soared to victory against TP Mazembe in the semifinal second leg of the CAF Champions League.
It was a tense showdown between Mamelodi Sundowns and Espérance Sportive de Tunis in the CAF Champions League semi-final.
