Hirvin Lonzano and Uriel Antuna scored to hand the Tricolors a convincing victory over the Black Stars. Heading into the game, the Mexican had not lost in their last five games and had scored 11 and conceded.
Chris Hughton on the hand had not lost in his previous five games as Ghana manager but could not maintain his record as his side succumbed to the Mexicans.
Here are three things we learned at the Bank of America stadium.
Hughton and Black Stars have never been a natural fit.
What has quickly become evident, even for those who deemed the Black Stars manager's appointment a necessary evil following poor results on the pitch, is the extent to which considerable frustration has started to set in on the terraces as he has been unable progress the team stylistically.
This was again apparent on Sunday. Of course, not all of the ire has been directed solely at Hughton; nor is Black Stars' current predicament entirely of his making. But the obvious point to make is that if the 64-year-old cannot win supporters round following a sustained run of improved form, then he will never be able to do so. Comments about winning 'the hearts and minds' of Black Stars smacked of Trump levels of delusion and spin.
Results, clearly, are only part of the story for the the Black Stars and their manager - certainly in the manner they are currently being achieved. Few, in truth, want the increasingly unpopular Hughton to be part of the team's future.
Selfish Kudus
Make no mistake, Mohammed Kudus is an outrageously talented and gifted footballer. With a wand of a left and lethal foot and, coupled with his insane finishing skills, he is a delight to watch every time he takes on to the field.
But in the last few games for the Black Stars, we have seen a change in the way Kudus approaches his game, and it's not exactly a good change. In this game, Kudus was culpable of being too selfish at times, and not for the first time in recent outings for the Black Stars.
Now normally you can put that down to overconfidence or the exuberance of youth, but there is a pattern emerging in Kudus' play which is evidence of the fact that he is trying to do too much himself. There is no doubt that he will go on to become a brilliant footballer in his own right, but he will have to learn to pick and choose his opportunities based on the situations in the game.
Thomas Partey embodies Black Stars’ strength in depth
He may not have had too much looks in the game but Thomas Partey provided a remainder that he is real weapon in Hughton's armoury.
An energetic presence throughout, the Arsenal midfielder shielded the ball with aplomb and showcased the desire to carry the ball forward when he did win it back. His agility and passing range caught the eyes on the break and allowed Antoine Semenyo and Mohammed Kudus to work their way into one-on-one situations. When he was subbed off at halftime, Ghana's midfield became practically non-existent.
It’s that depth that will give Ghana the best chance of excelling in January's AFCON.

